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Summer Vacation
I’m going to take a break from posting from now through August.
Jun 25
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Jesse Johnson
2
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Summer Vacation
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The first "AI Scientist" won't be a chat bot
I’ve been wanting to write about the interesting work that FutureHouse has been doing on reasoning models for biology, but I’m torn about how to frame…
Jun 18
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Jesse Johnson
2
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The first "AI Scientist" won't be a chat bot
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Did a foundation model just solve virtual small molecule screening?
Last week, a team of researchers at MIT, with support from Recursion, published a new foundation model called Boltz-2 that a lot of people are very…
Jun 11
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Jesse Johnson
6
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Did a foundation model just solve virtual small molecule screening?
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Can AI solve drug repurposing?
Nature Medicine recently published an article called A foundation model for clinician-centered drug repurposing that caught my attention because its use…
Jun 4
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Jesse Johnson
1
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Can AI solve drug repurposing?
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May 2025
Can you model biology mechanistically?
As part of the new direction that I’ve been taking this newsletter in, I’ve been exploring a bunch of different scientific applications of AI in pharma…
May 28
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Jesse Johnson
4
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Can you model biology mechanistically?
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Are foundation models the new moat?
Back in April, Tempus AI announced a strategic agreement with the pharma company AstraZeneca and a startup called Pathos, to build a Biology Foundation…
May 21
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Jesse Johnson
4
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Are foundation models the new moat?
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Autonomous Discovery Starts with Automation
Two weeks ago, I wrote about an emerging category of software using LLMs to help labs translate manual experiment protocols into automation scripts.
May 14
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Jesse Johnson
3
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Autonomous Discovery Starts with Automation
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Can an AI beat an in vivo model?
Last week, Axiom Bio came out of stealth mode with the goal of eliminating drug toxicity without using animals.
May 7
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Jesse Johnson
4
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Can an AI beat an in vivo model?
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April 2025
Is it an AI scientist or a Potato?
Potato (yes, that’s its name), a startup building “Autonomous agents for science,” recently announced a $4.5M funding round. This is big sign of…
Apr 30
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Jesse Johnson
7
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Is it an AI scientist or a Potato?
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The race begins for an FDA-approved AI toxicity model
The FDA recently announced that they’re working on phasing out animal testing requirements in favor of “AI-based computational models”, at least for…
Apr 23
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Jesse Johnson
4
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The race begins for an FDA-approved AI toxicity model
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What will happen to Dotmatics now?
The big news this month, just in time for the annual Bio-IT conference, was the acquisition of Dotmatics by Siemens for $5.1 billion.
Apr 16
•
Jesse Johnson
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What will happen to Dotmatics now?
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A new(ish) Scaling Biotech
After the brief hiatus I announced in March, I've decided to make some changes to this newsletter that I think will make it more interesting both for…
Apr 15
•
Jesse Johnson
5
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A new(ish) Scaling Biotech
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